Daily Archives: April 7, 2011

Fait Diver: Of Mice and Gay Men

mickey

Now let’s not panic but —

“MOLECULAR REGULATION OF SEXUAL PREFERENCE REVEALED BY GENETIC STUDIES OF 5-HT IN THE BRAINS OF MALE MICE!”

Can I get an “Oh Prunella!” ?

“Although the question of to whom a male directs his mating attempts1, 2 is a critical one in social interactions, little is known about the molecular and cellular mechanisms controlling mammalian sexual preference. Here we report that the neurotransmitter 5-hydroxytryptamine (5-HT) is required for male sexual preference. Wild-type male mice preferred females over males, but males lacking central serotonergic neurons lost sexual preference although they were not generally defective in olfaction or in pheromone sensing. A role for 5-HT was demonstrated by the phenotype of mice lacking tryptophan hydroxylase 2 (Tph2), which is required for the first step of 5-HT synthesis in the brain. Thirty-five minutes after the injection of the intermediate 5-hydroxytryptophan (5-HTP), which circumvented Tph2 to restore 5-HT to the wild-type level, adult Tph2 knockout mice also preferred females over males. These results indicate that 5-HT and serotonergic neurons in the adult brain regulate mammalian sexual preference.”

Do Tell Michelle!

Well you’ve have to get a subscription to Nature to read the whole bloody thing, but I’m certain there’s nothing in it that wasn’t revealed years ago by Monty Python.

Needless to say, cheese is only part of it. Mice Men are superb fashion designers. Just look at the work done by this soignee rodent —

YSL1

YSL2

Gus Gus will sing (and sew) us out.